Supplemental data from: Global differences in risk factors, etiology and outcome of ischemic stroke in young adults

Objective: To study the global distribution of risk factors, causes and 3-month mortality of young ischemic stroke patients, by performing a patient data meta-analysis form different cohorts worldwide. Methods: We did a pooled analysis of individual patient data from cohort studies which included consecutive ischemic stroke patients aged 18-50 years. We studied differences in prevalence of risk factors and causes between different ethnic groups, geographic regions and countries with different income levels. We investigated differences in 3-month mortality by mixed-effects multivariable logistic regression. Results: We included 17,663 patients from 32 cohorts in 29 countries. Hypertension and diabetes were most prevalent in Blacks (hypertension, 52.1%; diabetes, 20.7%) and Asians (hypertension 46.1%, diabetes, 20.9%). Large vessel atherosclerosis and small vessel disease were more often cause of stroke in high-income countries (HICs; both p&lt;0.001), whereas ‘’other determined s...研究目的：通过对全球多队列研究的个体患者数据（individual patient data）开展荟萃分析（meta-analysis），探究青年缺血性脑卒中（ischemic stroke）患者的危险因素、病因分布及3个月死亡率的全球流行特征。 研究方法：本研究对纳入18~50岁连续性缺血性脑卒中患者的队列研究（cohort studies）的个体患者数据进行合并分析。我们分析了不同种族、地理区域及不同收入水平国家间，危险因素与病因的患病率差异；并采用混合效应多变量logistic回归（mixed-effects multivariable logistic regression）模型，探究3个月死亡率的组间差异。 研究结果：本研究共纳入29个国家的32个队列的17663例患者。黑人群体中高血压与糖尿病的患病率最高（高血压：52.1%；糖尿病：20.7%），亚裔群体中高血压患病率为46.1%、糖尿病为20.9%。高收入国家（HICs）中，大动脉粥样硬化与小血管病变是更为常见的脑卒中病因（两者均p<0.001），而"其他明确病因...