ViCE Histopathology Images

72 Normal 0 false false false EN-US X-NONE X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman",serif;}The tissue morphology of the intestinal surface is architecturally complex with finger-like projections called villi, and glandular structures called crypts. The ratio of villus height-to-crypt depth ratio (Vh:Cd) is used to quantitatively assess disease severity and response to therapy for intestinal enteropathies, such as celiac disease and is currently quantified manually. Given the time required, manual Vh:Cd  measurements have largely been limited to clinical trials and are not used widely in clinical practice. We developed ViCE (Villus Crypt Evaluator), a user-friendly software that automatically quantifies histological parameters in standard hematoxylin and eosin (H&E) stained intestinal biopsies. ViCE is based on mathematical morphology operations and is scale and staining agnostic. It evaluates tissue orientation, identifies geometrical structure, and outputs key tissue measurements. These measurements are concordant with manual quantifications across multiple datasets. The underlying mathematical morphological approach for ViCE is robust, and reproducible and easily adaptable for measurement of morphological features in other tissues.   

肠道表面的组织形态结构复杂，存在被称为绒毛（villi）的指状突起与隐窝（crypts）状腺体结构。绒毛高度与隐窝深度的比值（Vh:Cd）可用于定量评估乳糜泻（celiac disease）等肠道肠病的疾病严重程度与治疗响应，当前该指标仍需通过人工方式测定。由于人工测量耗时较长，Vh:Cd的人工测定目前大多仅应用于临床试验，并未在临床实践中广泛普及。我们研发了ViCE（Villus Crypt Evaluator，绒毛隐窝评估器），一款操作简便的软件，可自动定量分析标准苏木精-伊红（hematoxylin and eosin，H&E）染色的肠道活检组织的形态学参数。ViCE基于数学形态学运算，不受成像尺度与染色条件的影响。该软件可评估组织取向、识别几何结构，并输出关键的组织测量指标。其测量结果与多数据集下的人工定量结果具有一致性。ViCE所采用的数学形态学方法鲁棒性强、可重复性佳，且易于适配其他组织的形态特征测量。

搜集汇总

背景与挑战

背景概述

该数据集名为ViCE Histopathology Images，是一个包含四个不同H&E染色肠道活检图像的数据集，用于支持ViCE软件自动量化绒毛高度与隐窝深度比（Vh:Cd）等组织形态参数，以评估肠道疾病严重性。数据集属于生物医学和健康科学领域，数据格式为图像，旨在替代手动测量，提高临床实践和研究的效率与可重复性。