These saturating mutagenesis screens of CDK4 and CDK6 resistance to palbociclib were part of a larger study defining the landscape of ATP-competitive inhibitor resistance residues in protein kinases.
Neuropilin-1 (NRP1) is overexpressed in various malignant solid tumors, modulating the tumor microenvironment (TME) via multiple mechanisms to promote immune suppression, angiogenesis, and epithelial-
TP53 status and pathogenicity for each model utilized for this study. Mutation status was derived from DepMap (https://depmap.org/portal/) for cell lines or provided by the PDX CRO.
