Activity-based protein profiling (ABPP) has emerged as a valuable chemical proteomics method to guide the therapeutic development of covalent drugs by assessing their on-target engagement and off-targ

NIAID Data Ecosystem120

Chemical Proteomic Profiling of Bromodomains Enables the Wide-Spectrum Evaluation of Bromodomain Inhibitors in Living Cells

溴结构域抑制剂

化学蛋白质组学

Bromodomains, epigenetic “readers” of lysine acetylation marks, exist in different nuclear proteins with diverse biological functions in chromatin biology. Malfunctions of bromodomains are associated

NIAID Data Ecosystem50

TMT10_hela-ip-buf-pal_1_4_frag_ms2_140min.raw

化学蛋白质组学

药物靶点鉴定

hela treated with DMSO, Bufalin-photoaffinity probe, and Bufalin-photoaffinity probe competed with bufalin

Figshare2022-10-06 更新10