These are peer-reviewed supplementary materials for the article ' Evaluation of emerging NASH therapies: the impact of treatment efficacy profiles on long-term health outcomes</
The liver is the central organ for cholesterol synthesis and homeostasis. The effects of dietary cholesterol on hepatic injury, mainly of oxidized low-density lipoproteins (OxLDL), are not fully under
To understand the fibrotic response in the CDA-HFD induced NASH fibrosis model, we performed RNA-seq on liver samples collected from mice fed with normal chow (week 0) or CDA-HFD chow (weeks 8 and 16)
We performed RNA-seq of livers obtained from 2 different NASH mouse models NASH was induced in mice using two different approaches. In the first study, male C57BL/6 mice were fed with a methionine and
