To see what other genetic markers outside of the MHC and NKC regions (in our animals) correlate to viral resistance. Conclusion: H-2Dk (or Dk) bearing animals typically increase their frequency of Ly
(A) Splenic viral titers and (B-F) escape (Δm157) frequency determined five days after a mixed MCMV infection (20000 PFU/mouse), as in Fig 1. (D) Anti-IFNAR1 antibody (or isotype control) was administ
Structure of alpha-galactosylphytosphingosine bound by CD1d and in complex with the Va14Vb8.2 TCR Descriptor: (2S,3S,4R)-2-amino-3,4-dihydroxyoctadecyl alpha-D-galactopyranoside, 2-acetamido-2-deoxy-b
Here we analyzed the transcriptional response to IL2 in NK cells in vitro. Splenic NK cells were isolated by negative selection from 6wk old male C57BL/6 mice. These were directly cultured with IL2 (2
Single-cell RNA-sequencing revealed increased pAMPK signaling and a unique gene expression signature. Our data demonstrate that Cox10 is required by NK cells to expand in response to Ly49H stimulation