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In vitro DNA synthesis opposite oxazolone and repair of this DNA damage using modified oligonucleotides
Emphasis was placed in this work on the assessment of biological features of 2,2,4-triaminooxazolone, a major one-electron and (·)OH-mediated oxidation product of guanine. For this purpose, two oligon
PubMed Central2000-04-01 更新60
A link between DNA methylation and epigenetic silencing in transgenic Volvox carteri
Epigenetic silencing of foreign genes introduced into plants poses an unsolved problem for transgenic technology. Here we have used the simple multicellular green alga Volvox carteri as a model to ana
PubMed Central2001-03-15 更新50
Gene expression changes in response to E2F1 activation
The p16/RB/E2F regulatory pathway, which controls transit through the G1 restriction point of the cell cycle, is one of the most frequent targets of genetic alterations in human cancer. Any of these a
PubMed Central2002-04-15 更新20
Transcriptional activation by LR1 at the Eµ enhancer and switch region sites
LR1 is a B cell-specific, sequence-specific duplex DNA binding activity which is induced in B cells carrying out class switch recombination. Here we identify several properties of LR1 which enable it
PubMed Central2000-07-15 更新60
Covalent cross-linking of duplex DNA using 4-thio-2'-deoxyuridine as a readily modifiable platform for introduction of reactive functionality into oligonucleotides.
Full details of the template-directed covalent cross-linking of duplex oligodeoxynucleotides are presented. 4-Thio-2'-deoxyuridine was incorporated synthetically into a 17mer oligodeoxynucleotide, and
PubMed Central1997-12-01 更新40
