Associations between tau, Aβ, and cortical thickness with cognition in Alzheimer disease

Objective To examine the cross-sectional associations between regional tau, β-amyloid (Aβ), and cortical thickness and neuropsychological function across the preclinical and clinical spectrum of Alzheimer disease (AD). Methods We included 106 participants from the Swedish Biomarkers for Identifying Neurodegenerative Disorders Early and Reliably (BioFINDER) study, of whom 33 had preclinical AD (Aβ-positive cognitively normal individuals), 25 had prodromal AD (Aβ-positive mild cognitive impairment), and 48 had probable AD dementia. All underwent [18F]flortaucipir (tau) and structural MRI (cortical thickness), and 88 of 106 underwent [18F]flutemetamol (Aβ) PET. Linear regression models adjusted for age, sex, and education were performed to examine associations between 7 regions of interest and 7 neuropsychological tests for all 3 imaging modalities. Results In preclinical AD, [18F]flortaucipir, but not [18F]flutemetamol or cortical thickness, was associated with decreased global cognition,...研究目的：探究阿尔茨海默病（Alzheimer Disease, AD）临床前至临床全谱系中，区域性tau蛋白、β-淀粉样蛋白（β-amyloid, Aβ）、皮层厚度与神经心理学功能之间的横断面关联。研究方法：本研究纳入瑞典早期可靠识别神经退行性疾病生物标志物（Swedish Biomarkers for Identifying Neurodegenerative Disorders Early and Reliably, BioFINDER）队列的106名受试者，其中33例为临床前AD患者（Aβ阳性认知正常个体），25例为前驱期AD患者（Aβ阳性轻度认知障碍（mild cognitive impairment, MCI）患者），48例为很可能AD痴呆患者。所有受试者均接受[18F]氟替哌酯（[18F]flortaucipir，tau显像）与结构磁共振成像（structural MRI，皮层厚度检测），106名受试者中的88例额外完成[18F]氟甲醚醇（[18F]flutemetamol, Aβ）正电子发射断层显像（positron emission tomography, PET）。本研究采用校正年龄、性别与受教育程度的线性回归模型，对3种成像模态下的7个感兴趣区（regions of interest, ROI）与7项神经心理学测试之间的关联进行分析。研究结果：在临床前AD患者中，[18F]氟替哌酯显像与整体认知功能下降存在关联，而[18F]氟甲醚醇显像与皮层厚度则未表现出此类关联……