Type3_Diao_distr_1212_15_13_3_Enhancers

Figshare2019-06-20 更新2026-04-29 收录

CRISPRi筛选

增强子功能研究

数据链接：

https://figshare.com/articles/dataset/Type3_Diao_distr_1212_15_13_3_Enhancers/8251304 数据链接链接失效反馈

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资源简介：

Enhancer positions from simulated CRISPR regulatory screen. Type 3, medium guide counts, high selection strength

创建时间：

2019-06-20

Perturb-seq: Dissecting molecular circuits with scalable single cell RNA profiling of pooled genetic screens

单细胞转录组学

CRISPRi筛选

Methods: We create a CRISPR vector containing a polyadenylated RNA barcode and couple it with droplet scRNA-seq to get a large scale transcriptional measurements of perturbations Results: We were able

DataCite Commons2020-10-10 更新60

Additional file 6: of Genome-wide CRISPR screen reveals PSMA6 to be an essential gene in pancreatic cancer cells

胰腺癌

CRISPRi筛选

(Movies). Non-targeting siRNA (movie 1) and siPSMA6 (movie 2) were transfected at 25 nM into PANC-1 cells and images were acquired every 4 h with an IncuCyte Live Cell Analysis System. Non-targeting s

DataCite Commons2020-08-27 更新50

Targeting SUMO2 reverses aberrant epigenetic rewiring driven by SS18::SSX fusion oncoproteins and impairs sarcomagenesis [CRISPR Screening]

滑膜肉瘤治疗

CRISPRi筛选

Synovial sarcoma (SySa) is an aggressive soft tissue sarcoma with an urgent need to develop targeted therapies. Here, we exploited specific vulnerabilities created by transcriptional rewiring by the f

NIAID Data Ecosystem10

Additional file 16 of Identification of functional regulatory elements in the human genome using pooled CRISPR screens

CRISPRi筛选

功能基因组学

Additional file 16: Table S11. Guide-level MAGeCK output (Peak Library/Cas9/Untreated).

NIAID Data Ecosystem50

CRISPR screen identifies loss of IFNγR signaling and downstream adhesion as a resistance mechanism to CAR T-cell cytotoxicity in solid tumors

CART细胞抵抗机制

CRISPRi筛选

U87-CBG-GFP cells selected with blasticidin to stably express Cas9 were transduced with an MOI (< 1) of Brunello guide library (with puromycin resistance in the guide backbone). Cells were rested for

NIAID Data Ecosystem20

Type3_Diao_distr_1212_15_13_3_Enhancers

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