BindingDB Entry 50019421: Discovery of 4-amino-5,6-biaryl-furo[2,3-d]pyrimidines as inhibitors of Lck: development of an expedient and divergent synthetic route and preliminary SAR.

Small molecule binding data for protein Epidermal growth factor receptor, JAK3/JAK1, SRC, Tyrosine kinase non-receptor protein 2, Tyrosine-protein kinase JAK2, Tyrosine-protein kinase ZAP-70, VEGF-receptor 2 and tyrosine-protein kinase SRC, Vascular endothelial growth factor receptor 2, and Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2), Uniprot O60674, P00533, P06239, P12931, P35968, P43403, P52333, Q02763, and Q07912本数据集包含针对下述蛋白及蛋白组合的小分子结合数据：表皮生长因子受体（Epidermal growth factor receptor）、JAK3/JAK1、酪氨酸蛋白激酶SRC（SRC）、非受体酪氨酸蛋白激酶2（Tyrosine kinase non-receptor protein 2）、酪氨酸蛋白激酶JAK2（Tyrosine-protein kinase JAK2）、酪氨酸蛋白激酶ZAP-70（Tyrosine-protein kinase ZAP-70）、血管内皮生长因子受体2（VEGF-receptor 2），以及同时靶向血管内皮生长因子受体2（Vascular endothelial growth factor receptor 2）与酪氨酸蛋白激酶TIE-2（即KDR与TIE2）的组合靶点结合数据。数据集对应的通用蛋白数据库（UniProt）编号为：O60674、P00533、P06239、P12931、P35968、P43403、P52333、Q02763及Q07912。