UVDE-seq mapping of UV-induced non-CPD lesions

Here we have used a novel high-throughput sequencing method known as UVDE-seq to map the formation of non-CPD lesions at single nucleotide resolution across the yeast genome in wild-type and rad16 mutant cells, which are deficient in GG-NER.本研究采用一种名为UVDE-seq的新型高通量测序方法，在单核苷酸分辨率水平上，对野生型酵母细胞以及全局基因组核苷酸切除修复（Global Genomic Nucleotide Excision Repair，GG-NER）缺陷型rad16突变酵母细胞的全基因组范围内非环丁烷嘧啶二聚体损伤（non-CPD lesions）的形成分布进行了图谱绘制。