Additional file 1 of Effect of women’s fertility and sexual development on epigenetic clock: Mendelian randomization study

Additional file 1 Table S1. Mendelian randomization (MR) association estimates for exposures on outcomes. Table S2. Sensitive analysis. Table S3. Multivariable Mendelian randomization (MR) association estimates of female traits and BMI, insomnia, FBG, hypertension across PhenoAge. Table S4. Multivariable Mendelian randomization (MR) association estimates of female traits and BMI, insomnia, FBG, hypertension across GrimAge. Table S5. Multivariable Mendelian randomization (MR) association estimates of female traits and BMI, insomnia, FBG, hypertension across HannumAge. Table S6. Multivariable Mendelian randomization (MR) association estimates of female traits and BMI, insomnia, FBG, hypertension across HorvothAge. Table S7. Genetic instruments for AFS. Table S8. Genetic instruments for AFB. Table S9. Genetic instruments for AAM. Table S10. Genetic instruments for ANM. Table S11. Genetic instruments for NSP. Table S12. Genetic instruments for insomnia. Table S13. Genetic instruments for hypertension. Table S14. Genetic instruments for bmi. Table S15. Genetic instruments for fasting blood glucose. Table S16. Characteristics of the GWAS use in exposures and confounders.附加文件1 表S1：暴露因素对结局的孟德尔随机化（Mendelian randomization, MR）关联效应估计值。表S2：敏感性分析。表S3：多变量孟德尔随机化（MR）关联效应估计值：女性特征、体质量指数（Body Mass Index, BMI）、失眠、空腹血糖（fasting blood glucose, FBG）及高血压与PhenoAge的关联。表S4：多变量孟德尔随机化（MR）关联效应估计值：女性特征、体质量指数（BMI）、失眠、空腹血糖（FBG）及高血压与GrimAge的关联。表S5：多变量孟德尔随机化（MR）关联效应估计值：女性特征、体质量指数（BMI）、失眠、空腹血糖（FBG）及高血压与HannumAge的关联。表S6：多变量孟德尔随机化（MR）关联效应估计值：女性特征、体质量指数（BMI）、失眠、空腹血糖（FBG）及高血压与HorvathAge的关联。表S7：AFS的遗传工具变量。表S8：AFB的遗传工具变量。表S9：AAM的遗传工具变量。表S10：ANM的遗传工具变量。表S11：NSP的遗传工具变量。表S12：失眠的遗传工具变量。表S13：高血压的遗传工具变量。表S14：BMI的遗传工具变量。表S15：空腹血糖的遗传工具变量。表S16：用于暴露因素与混杂因素分析的全基因组关联研究（Genome-Wide Association Study, GWAS）的特征信息。