Association between dietary magnesium intake and hyperuricemia

Objective: To examine the cross-sectional associations between dietary magnesium (Mg) intake and hyperuricemia (HU). Methods: 5168 subjects were included in this study. Dietary intake was assessed using a validated semi-quantitative food frequency questionnaire. Hyperuricemia (HU) was defined as uric acid ≥ 416 mmol/L for male population and ≥ 360 mmol/L for female. A multivariable logistic analysis model was applied to test the associations after adjusting a number of potential confounding factors. Results: The relative odds of the overall prevalence of HU were decreased by 0.57 times in the fourth quintile of Mg intake (OR 0.57, 95% CI 0.35-0.94) and 0.55 times in the fifth quintile (OR 0.55, 95% CI 0.30-1.01) comparing with the lowest quintile, and P for trend was 0.091. The results of multivariable linear regression also suggested a significant inverse association between serum uric acid and Mg intake (β=-0.028, P=0.022). For male, the relative odds of HU were decreased by 0.62 time...研究目的：探讨膳食镁（Mg）摄入量与高尿酸血症（Hyperuricemia, HU）之间的横断面关联。研究方法：本研究共纳入5168名研究对象。采用经过验证的半定量食物频率问卷评估膳食摄入情况。高尿酸血症（HU）定义为男性血清尿酸≥416 mmol/L、女性血清尿酸≥360 mmol/L。本研究采用多变量logistic回归分析模型，在校正多项潜在混杂因素后，检验二者的关联。研究结果：相较于最低五分位数组，镁摄入量第四五分位数组人群的高尿酸血症总体患病相对比值比降低0.57倍（OR=0.57，95%CI 0.35~0.94），第五五分位数组降低0.55倍（OR=0.55，95%CI 0.30~1.01），趋势检验P值为0.091。多变量线性回归分析结果同样显示，血清尿酸水平与镁摄入量呈显著负相关（β=-0.028，P=0.022）。在男性人群中，高尿酸血症的相对患病风险降低0.62倍……