相关数据集
Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions
Proper genome functionality is underpinned by the non-random, spatial or ganisation of chromatin. At the periphery of the nucleus, the association of chr omatin with the nuclear lamina is thought to f
NIAID Data Ecosystem50
Promoter repression and 3D-restructuring resolves divergent developmental gene expression in TADs [Hi-C]
Cohesin loop extrusion facilitates precise gene expression by continuously driving promoters to sample all enhancers located within the same topologically-associated domain (TAD). However, many TADs c
NIAID Data Ecosystem20
Genome-wide maps of nuclear lamina interactions in AML12 cells upon Safb KD [DamID]
Eukaryotic chromosomes fold into topologically associating domains (TADs), which further gather in active (A) or inactive (B) genomic compartments. Here we show that Scaffold Attachment Factor B (SAFB
NIAID Data Ecosystem10
colon37_res1000000_chr21_cond1_4.matrix
matrix of 5th replicate, chr21, resolution 1Mb
Recherche Data Gouv France2024-01-01 更新40
Regulation of somatic hypermutation by higher-order chromatin structure [PRO-Seq]
The generation of protective antibodies by somatic hypermutation (SHM) is essential for antibody maturation and adaptive immunity. SHM involves co-transcriptional mutagenesis of immunoglobulin variabl
NIAID Data Ecosystem10
