Genome-wide maps of ONECUT2 binding sites in 22Rv1 human castration resistant prostate cancer cell

In order to determine whether ONECUT2 directly regulates the AR transcriptional program, or whether the effect of ONECUT2 is a mere consequence of AR downregulation, we performed ONECUT2 ChIP-sequencing (ChIP-seq) using the 22Rv1 human castration resistant prostate cancer cell line, which expresses high levels of ONECUT2 in comparison to other human prostate cancer cell lines Overall design: Genome-wide binding profile of ONECUT2 transcription factor in 22Rv1 cell.