Macromolecular crystallography at the Philipps University Marburg (MarBAG)

Located at the Philipps-University-Marburg and the Max-Planck-Institute for terrestrial Microbiology in Marburg, Germany, the MarBAG employs X-ray crystallography to answer fundamental questions involving synthesis and assembly of macromolecular machines and cellular structures (e.g. CO2-fixation pathways, flagellar biosynthesis, CRISPR-Cas Systems, cell-wall-related processes). Our analysis of the structural basis of CO2 fixation and the synthesis of the green-house gas methane will help to engineer these processes as tools in climate control. Furthermore, we are interested in plant-pathogen interactions and the function of nucleotide derived signalling molecules in cellular stress physiology and organization. Currently, a 200 keV cryo-electron microscope is being installed at the UMR to complement our efforts to structurally characterize macromolecular complexes, which do not readily crystallize.本数据集所属的MarBAG研究团队坐落于德国马尔堡的菲利普斯-马尔堡大学与马克斯·普朗克陆地微生物研究所，该团队借助X射线晶体衍射技术，针对大分子机器与细胞结构（例如二氧化碳固定途径、鞭毛生物合成、CRISPR-Cas系统、细胞壁相关过程）的合成与组装相关基础科学问题开展研究。本团队针对二氧化碳固定的结构基础以及温室气体甲烷合成过程的解析工作，将为通过工程化改造上述途径以开发气候调控工具提供有力支撑。此外，本团队的研究兴趣还涵盖植物与病原体的互作机制，以及核苷酸衍生信号分子在细胞应激生理与细胞结构组织中的功能。目前，一台200 keV冷冻电子显微镜正在UMR中安装，以辅助本团队对难以结晶的大分子复合物开展结构表征相关研究。