Transcriptome analysis of small molecule-mediated astrocyte-to-neuron reprogramming. Transcriptome analysis of small molecule-mediated astrocyte-to-neuron reprogramming

Human astrocytes can be efficiently reprogrammed into functional neurons in culture by the addition of four small molecules. RNA-seq was performed to assess transcriptome alterations at different time points to characterize the molecular mechanisms. Overall design: RNA profiles of small molecule-treated human astrocyte culture at 6 time points throughout reprogramming, 3 replicates each.