TRAIT

T-cell receptor–antigen interaction database (TRAIT) is a comprehensive database that profiles the interactions between TCRs and antigens. TRAIT was developed to explicitly characterize the interactions between TCRs and antigens by integrating sequences, structures, and binding affinities. TRAIT also offers single-cell-based antigen-specific TCR repertoires and systematically demonstrates interactions between mutations of TCRs and antigens. Additionally, clinical evaluations of antigen-specific TCRs were uniquely provided. Given the recent prominence of T-cell-based immunotherapies in disease treatment, the comprehensive data on TCR–antigen interactions provided by TRAIT are anticipated to better facilitate the discovery and optimization of TCR candidates for immunotherapies.T细胞受体（T-cell receptor, TCR）-抗原互作数据库（TRAIT）是一款全面刻画TCR与抗原互作关系的专业数据库。该数据库旨在通过整合序列、结构及结合亲和力数据，系统表征TCR与抗原之间的互作特征。此外，TRAIT还提供基于单细胞的抗原特异性TCR库，并系统展示了TCR突变体与抗原的互作模式。不仅如此，该数据库还独家收录了抗原特异性TCR的临床评估数据。鉴于基于T细胞的免疫疗法在疾病治疗领域的关注度与日俱增，TRAIT所提供的全面TCR-抗原互作数据，有望进一步助力免疫疗法候选TCR的筛选与优化工作。

搜集汇总

背景与挑战

背景概述

TRAIT是一个全面的T细胞受体-抗原相互作用数据库，整合了实验验证的交互和非交互对，提供序列、结构和亲和力等多维数据。其独特之处在于包含数百万非交互对和突变记录，支持TCR工程化、疫苗设计和免疫疗法开发，并涵盖临床试验数据。