PrPC-dependent gene expression and cell signalling signature in Neuro2a cells. Role on mitogenic stimulation and cell morphology.. Mus musculus

In this work we present the PrPC-dependent gene expression signature in N2A cells and its implication on the most overrepresented functions; cell cycle, cell growth and proliferation and cell morphology. Overall design: To evaluate the genes whose transcription was regulated after Prnp modulation, RNA samples were analyzed with Illumina mouse whole genome beadarrays. cell type comparison; genetic modification; RNA interference