Attempts at eradicating metastatic cancers with targeted therapies are limited by the emergence of resistant sub-clones bearing heterogeneous (epi)genetic changes. Here we use colorectal cancer to tes
This study aims to investigate the accumulation of genomic instability and chromosome segregation errors after the acquisition of resistance to CDK4/6i in ER+ breast cancer and to test the efficacy of
Results of knocking-down AREG expression in SUM-149 cells by lenitviral infection of shRNA vectors and measuring gene expression provides information as to what genes are regulated by AERG in inflamma
Malignant rhadboid tumours (MRTs) are lethal paediatric cancers characterised by a deficiency in the SWI/SNF subunit SMARCB1. Here we employ an integrated molecular profiling and chemical biology appr