TMA-RAW DATA.xlsx

A total of 73 colorectal cancer tissues and normal colorectal mucosa tissues were collected from different selected patients in each tissue microarray slide. The tissue microarrays (TMA) were scored blindly by a clinical pathologist. Total and nuclear PLA signals were evaluated for both IGF-1R/NuMA and 53BP1/NuMA. Tumors were arbitrary classified for statistical comparisons: tumor with no or very few signals were scored as 0-1 (negative / weak); tumors with moderate signals (5-10 per cell/nuclei in the majority of cells) were scored as 2 (intermediate), and tumors with abundant signals (>10 signals per cell / nuclei in the majority of cells) were scored as 3 (strong).本研究从各组织微阵列（Tissue Microarray, TMA）载片中的不同入组患者体内，共采集了73份结直肠癌组织与正常结直肠黏膜组织。上述组织微阵列由一名临床病理学家采用盲法完成评分。本研究对IGF-1R/NuMA与53BP1/NuMA两组的总PLA信号及核内PLA信号均进行了评估。为开展统计学比较，本研究对肿瘤样本进行了分级：无信号或信号极稀少的肿瘤被评为0~1级（阴性/弱阳性）；多数细胞/细胞核内信号量中等（每细胞/细胞核5~10个）的肿瘤被评为2级（中等阳性）；多数细胞/细胞核内信号丰富（每细胞/细胞核信号数＞10）的肿瘤被评为3级（强阳性）。