首页/数据集/Analysis of quinazoline and PYRIDO[2,3D]PYRIMIDINE N9-C10 reversed bridge antifolates in complex with NADP+ and Pneumocystis carinii dihydrofolate reductase

Analysis of quinazoline and PYRIDO[2,3D]PYRIMIDINE N9-C10 reversed bridge antifolates in complex with NADP+ and Pneumocystis carinii dihydrofolate reductase

NIAID Data Ecosystem2026-05-01 收录

抗叶酸药物设计

二氢叶酸还原酶抑制

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https://www.rcsb.org/structure/1LY4 数据链接链接失效反馈

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资源简介：

Analysis of quinazoline and PYRIDO[2,3D]PYRIMIDINE N9-C10 reversed bridge antifolates in complex with NADP+ and Pneumocystis carinii dihydrofolate reductase

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创建时间：

2024-02-14

抑制剂结构

抗叶酸药物设计

E. coli dihydropteroate synthase complexed with an 8-mercaptoguanine derivative: 2-azanyl-8-[(2-fluorophenyl)methylsulfanyl]-1,9-dihydropurin-6-one Descriptor: 2-azanyl-8-[(2-fluorophenyl)methylsulfan

Protein Data Bank Japan2023-10-04 更新50

Human dihydrofolate reductase complexed with NADPH and 5-{3-[3-methoxy-5-(isoquin-5-yl)phenyl]but-1-yn-1-yl}6-ethylpyrimidine-2,4-diamine

药物靶点结构

抗叶酸药物设计

Human dihydrofolate reductase complexed with NADPH and 5-{3-[3-methoxy-5-(isoquin-5-yl)phenyl]but-1-yn-1-yl}6-ethylpyrimidine-2,4-diamine Descriptor: 6-ethyl-5-{(3S)-3-[3-(isoquinolin-5-yl)-5-methoxyp

Protein Data Bank Japan2023-09-20 更新40

Human dihydrofolate reductase complexed with NADPH and 5-{3-[3-methoxy-5(pyridine-4-yl)phenyl]prop-1-yn-1-yl}-6-ethyl-pyrimidine-2,4-diamine

抑制剂结构

抗叶酸药物设计

Human dihydrofolate reductase complexed with NADPH and 5-{3-[3-methoxy-5(pyridine-4-yl)phenyl]prop-1-yn-1-yl}-6-ethyl-pyrimidine-2,4-diamine Descriptor: 6-ethyl-5-{3-[3-methoxy-5-(pyridin-4-yl)phenyl]

Protein Data Bank Japan2023-09-20 更新40

6-substituted pyrido[3,2-d]pyrimidine--6-4'-trifluoromethoxyphenyl)

药物靶点结构

抗叶酸药物设计

6-substituted pyrido[3,2-d]pyrimidine--6-4'-trifluoromethoxyphenyl) Descriptor: Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, N~6~-methyl-N~6~-[4-(trifluoromethox

Protein Data Bank Japan2023-09-27 更新40

Human dihydrofolate reductase ternary complex with NADPH and inhibitor 26 (N~6~-METHYL-N~6~-(3,4,5-TRIFLUOROPHENYL)PYRIDO[2,3-D]PYRIMIDINE-2,4,6-TRIAMINE)

抑制剂结构

抗叶酸药物设计

Human dihydrofolate reductase ternary complex with NADPH and inhibitor 26 (N~6~-METHYL-N~6~-(3,4,5-TRIFLUOROPHENYL)PYRIDO[2,3-D]PYRIMIDINE-2,4,6-TRIAMINE) Descriptor: Dihydrofolate reductase, NADPH DI

Protein Data Bank Japan2023-09-20 更新40

Analysis of quinazoline and PYRIDO[2,3D]PYRIMIDINE N9-C10 reversed bridge antifolates in complex with NADP+ and Pneumocystis carinii dihydrofolate reductase

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