Additional file 1 of Design of chimeric GLP-1A using oligomeric bile acids to utilize transporter-mediated endocytosis for oral delivery

Additional file 1: Fig. S1. In silico molecular docking analysis for estimated Ki and binding energy of oligomeric DOCAs to ASBT. Fig. S2. A Residue interacting of monoDOCA and bisDOCA to the ASBT binding cavity, and the type of interaction. B Overall interactions between oligomeric DOCAs and ASBT. Fig. S3. Ligand RMSD of oligomeric DOCA-G1A during 100 ps of MD simulation. Fig. S4. The DOCA motif region of mD-G1A that directly interacts with the ASBT binding site for motif-specific interaction energy calculation. Fig. S5. 1H-NMR (500 MHz) of the oligomeric DOCAs. A monoDOCA, B bisDOCA, and C tetraDOCA. Fig. S6. 1H-NMR (500 MHz) of the oligomeric DOCA-EMCS conjugates. A monoDOCA-EMCS, B bisDOCA-EMCS, and C tetraDOCA-EMCS. Fig. S7. MALDI-TOF MS results of the oligomeric DOCA-EMCS conjugates (monoDOCA-EMCS, bisDOCA-EMCS, and tetraDOCA-EMCS).