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The 3D Genomic Landscape of Differential Response to EGFR/HER2 Inhibition in Endocrine-Resistant Breast Cancer

NIAID Data Ecosystem2026-03-12 收录

癌症精准治疗

HER2靶向治疗

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE144380 数据链接链接失效反馈

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资源简介：

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

应用场景：

创建时间：

2020-12-01

化疗耐药机制

HER2靶向治疗

Targeting HER2 with lapatinib (L), trastuzumab (T), or the LT combination, is effective in HER2+ breast cancer (BC), but de novo and acquired resistance commonly occur. The purpose of this experiment

NIAID Data Ecosystem60

A Study of T-DXd for the Treatment of Solid Tumors Harboring HER2 Activating Mutations

HER2靶向治疗

精准医疗临床试验

This is an open-label, multi-center, single arm, Phase II study to evaluate the efficacy and safety of T-DXd for the treatment of unresectable and/or metastatic solid tumors harboring specific HER2 ac

NIAID Data Ecosystem30

Clinicopathological features of included cases.

乳腺癌分子分型

HER2靶向治疗

Purpose HER2-low has garnered significant attention for the treatment of HER2-negative breast cancer. We aimed to determine the prevalence of HER2-low expression in Hispanic/Latino women with breast c

NIAID Data Ecosystem20

Acquired HER2 mutations in ER+ metastatic breast cancer confer resistance to ER-directed therapies. Acquired HER2 mutations in ER+ metastatic breast cancer confer resistance to ER-directed therapies

化疗耐药机制

HER2靶向治疗

Estrogen receptor positive (ER+) breast cancers that develop resistance to therapies that target the ER are the most common cause of breast cancer death. Beyond mutations in ER, which occur in 25-30%

NIAID Data Ecosystem40

Deconvolution of breast tumors for optimal chemotherapy selection

肿瘤微环境

癌症精准治疗

Extensive work in pre-clinical models has shown that microenvironmental cells influence many aspects of cancer cell behavior including metastatic potential and their sensitivity to therapeutics. In th

NIAID Data Ecosystem20

The 3D Genomic Landscape of Differential Response to EGFR/HER2 Inhibition in Endocrine-Resistant Breast Cancer

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