High-throughput phenotypic screening against yeast Saccharomyces cerevisiae revealed a series of triazolo-pyrimidine-sulfonamide compounds with broad-spectrum antifungal activity, no significant cytot
Sanguisorbae Radix (SR) has been employed as an herbal medicine over centuries. Charred SR (CSR), acquired via carbonization after the charred stir-frying of SR, demonstrates superior antimicrobial ac
Crystal structure of sterol 14-alpha demethylase (CYP51) from a pathogenic yeast Candida albicans in complex with the antifungal drug posaconazole Descriptor: CYP51 VARIANT1, POSACONAZOLE, PROTOPORPHY
Background Polypharmacy and potential drug-drug interactions (pDDIs) are major challenges in the management of elderly patients with multiple comorbidities, often leading to adverse drug events and in
Fungi are closely associated with various diseases, with Candida albicans (C. albicans) recognized as an important pathogenic fungus in inflammatory bowel disease (IBD). Fungal pathogenicity is primar
