Isoquinolone Synthesis through S<sub>N</sub>Ar Reaction of 2‑Halobenzonitriles with Ketones Followed by Cyclization
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An efficient method for the synthesis of isoquinolones through base KOtBu-promoted SNAr reaction of 2-halobenzonitriles with ketones followed by Lewis acid Cu(OAc)2-catalyzed cyclization is described. Isoquinolone derivatives were obtained in satisfactory to good yields.
创建时间：
2016-02-13
