A functional screening strategy for engineering chimeric antigen receptors with reduced on-target, off-tumour activation. Mus musculus
收藏NIAID Data Ecosystem2026-03-11 收录
官方服务：
资源简介：
Raw sequence reads of post-selection libraries
应用场景：
创建时间：
2020-07-30
相关数据集
Massively parallel engineering of persistent CAR-Ts [GEO_CLASH_MIPS]. Massively parallel engineering of persistent CAR-Ts [GEO_CLASH_MIPS]
To identify immune-related gene perturbations that enhance CAR-T cell persistence in in vitro and in vivo settings, we generated thousands of CAR-T variants using the CLASH platform and evaluated crRN
NIAID Data Ecosystem80
Genome-wide maps of chromatin state in human primary CAR-T cells [ChIPseq, ATAC-seq]
We report the transcriptomic and epigentic profile of human primary CD19-28z CAR-T cells. Overall design: CRISPR gene editing was used to delete MED12 or the "safe harbor" control gene AAVS1. Gene-edi
NIAID Data Ecosystem40
CAR T cells Overexpressing cJun Are Exhaustion-Resistant and Mediate Enhanced Antitumor Activity. CAR T cells Overexpressing cJun Are Exhaustion-Resistant and Mediate Enhanced Antitumor Activity
CAR T cells mediate antitumor effects in a small subset of cancer patients, but dysfunction due to T cell exhaustion is an important barrier to progress. To investigate the biology of exhaustion in hu
NIAID Data Ecosystem20
Parsing digital or analogue TCR performance through piconewton forces. Parsing digital or analogue TCR performance through piconewton forces
T lymphocytes leverage T-cell receptor (TCR) recognition of aberrant peptides bound to major histocompatibility complex molecules (pMHCs) on altered cells to protect the mammalian host from infectious
NIAID Data Ecosystem40
Tumor-site directed A1R expression enhances CAR T cell function and improves efficacy against solid tumors. [CD8 inducible human RNAseq]
The efficacy of Chimeric Antigen Receptor (CAR) T cells against solid tumors is limited by immunosuppressive factors in the tumor microenvironment (TME) including adenosine, which suppresses CAR T cel
NIAID Data Ecosystem30
