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2021-04-26
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Computational approach identifies protein off-targets for Isoniazid-NAD adduct: hypothesizing a possible drug resistance mechanism in Mycobacterium tuberculosis
Isoniazid is an important antitubercular molecule identified as a drug of choice in tuberculosis treatment. As such, INH is an inactive prodrug; it acquires an active conformation by forming an adduct
DataCite Commons2020-08-27 更新230
Gemcitabine Drug resistance. Homo sapiens
KBwt is a KB parental cell KBHURs is a hydroxyurea resistant KB clone KBGem is a gemcitabine resistant KB clone Keywords: HU95 V2 Overall design: We extracted the RNA from KBwt, KBHURs and KBGem clone
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Human-Like Receptor Specificity Does Not Affect the Neuraminidase-Inhibitor Susceptibility of H5N1 Influenza Viruses
If highly pathogenic H5N1 influenza viruses acquire affinity for human rather than avian respiratory epithelium, will their susceptibility to neuraminidase (NA) inhibitors (the likely first line of de
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人套细胞淋巴瘤细胞JeKo-1
一位套细胞淋巴瘤患者的巨细胞变种显示白血病转变，从其外周血单核细胞出发建立了MCL细胞株JeKo-1。JeKo-1细胞EB病毒阴性，并表达一种B细胞表型的IgM。细胞过表达cyclin D1, Bcl-2, c-Myc 及 Rb 蛋白。 Bcl-1/J(H)基因重排得到了PCR证实。 JeKo-１细胞在SCID小鼠中高成瘤。在本库通过支原体检测。在本库通过STR检测。其重要性在于可为生命科学和生物
中国科技资源共享网2026-01-25 更新110
In silico study of colchicine resistance molecular mechanisms caused by tubulin structural polymorphism
Starting from 1972, colchicine is known as the most useful drug for prevention of familial Mediterranean fever attacks. However, some patients do not respond to colchicine treatment, even taken in hig
NIAID Data Ecosystem30
