Fourth-generation EGFR tyrosine kinase are in development to overcome common resistance mutations. We performed deep mutational scanning (DMS) of the EGFR kinase domain in the context of L858R by intr

NIAID Data Ecosystem20

Fitness and functional landscapes of the E. coli RNase III gene rnc. Escherichia coli

蛋白质适应性

深度突变扫描

The relationships between protein sequence, protein structure, protein function, and organismal fitness are key to understanding the molecular basis for the fitness effects of mutations. How protein p

NIAID Data Ecosystem50

SeprotHub/Dataset-RASH_HUMAN

蛋白质突变预测

深度突变扫描

该数据集包含了人类RASH蛋白质单点突变及其对应的突变效应分数，这些分数来自于深度突变扫描实验。蛋白质的格式为氨基酸序列。数据集分为训练集、验证集和测试集，分别包含2479、338和317个样本。标签表示基于深度突变扫描实验的每个蛋白质的突变效应分数，范围从负无穷大到正无穷大，其中0代表野生型的值，数值越大表示适应性越高。

Hugging Face2025-05-13 更新40

Comprehensive fitness landscape of SARS-CoV-2 Mpro in S. cerevisiae - raw sequence reads

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