Transcriptomic study on human skin samples: identification of actinic keratoses two risk classes.

Gene expression profile analysis allowed to identify 2 classes of AK. A total of 72 tissue samples (24 NL, 23 L, 4 PL and 21 AK) were isolated from 24 patients. For each patient, samples were acquired on the lesion (L or AK), on the perilesional (PL) i.e. safety surgical margin area (often containing AK) and/or on the non-lesional (NL) parts of the elliptical surgical excision.