Regulation of T cell exhaustion and PD-1 targeted immunotherapy by mTOR during chronic viral infection

NIAID Data Ecosystem2026-03-14 收录

T细胞耗竭

PD-1靶向免疫治疗

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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE215248 数据链接链接失效反馈

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RNA-Sequence data of stem-like and TIM3+ differentiated CD8 T cells generated in rapamycin treated mice Gene expression profilng by high throughput sequencing

创建时间：

2023-02-07

Single cell RNAseq of Wild Type and IL27ra KO Tumor infiltrating lymphocytes isolated from B16F10 melanoma batch 1. Single cell RNAseq of Wild Type and IL27ra KO Tumor infiltrating lymphocytes isolated from B16F10 melanoma batch 1

单细胞免疫组学

T细胞耗竭

Expression of co-inhibitory receptors, such as CTLA-4 and PD-1, on effector T cells is a key mechanism for ensuring immune homeostasis. Dysregulated co-inhibitory receptor expression on CD4+ T cells p

NIAID Data Ecosystem20

Table S14 from Presence of Tertiary Lymphoid Structures and Exhausted Tissue-Resident T Cells Determines Clinical Response to PD-1 Blockade in Renal Cell Carcinoma

肿瘤免疫治疗

T细胞耗竭

Differential gene expression analysis, including differentially expressed genes for ZNF683+ SLAMF7+ CD8+ Exhausted T cells compared to all other T cell clusters, related to Figure 5. Positive log fold

NIAID Data Ecosystem10

The Transcriptome of over expressed SLAMF6 isoform-3 in activated Jurkat cell line. The Transcriptome of over expressed SLAMF6 isoform-3 in activated Jurkat cell line

T细胞耗竭

剪接异构体调控

SLAMF6 is a homotypic receptor of the Ig-superfamily associated with progenitor exhausted T cells. In humans, SLAMF6 has three splice isoforms involving its V-domain.We KO isoform 1 of SLAMF6 in a Jur

NIAID Data Ecosystem10

Effect of depletion of Bcor, Zc3h12a or both on chromatin accessibility of P14 CD8 T cells at single cell level [scATAC-seq]

细胞染色质可及性分析

T细胞耗竭

In chronic viral infections, sustained CD8+ T cell response relies on TCF1+ precursor exhausted T cells (TPEX) exhibiting stem-like properties. TPEX self-renew and respond to PD-1 blockade, underscori

NIAID Data Ecosystem20

Themis directs T cell exhaustion by promoting PD-1 signaling and key transcription factors TCF-1 and TOX expression

T细胞耗竭

单细胞转录组学

We adopted scRNA-seq to examine whether Themis is required for Tex initiation. To strengthen the rigorousness of scRNA-seq analysis, we contransferred P14 WT and P14 Themis cKO cells, enabling them to

NIAID Data Ecosystem10

Regulation of T cell exhaustion and PD-1 targeted immunotherapy by mTOR during chronic viral infection

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