Homo sapiens Targeted Locus (Loci). Homo sapiens
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Rescue of high-specificity Cas9 variants using sgRNAs with matched 5' nucleotides
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2017-09-25
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Additional file 17 of Epigenetic reactivation of tumor suppressor genes with CRISPRa technologies as precision therapy for hepatocellular carcinoma
Additional file 17: Data S6. Related to Figure S6. Probe methylation (beta) values for HHIP in transiently transfected Hep3B cells with SpdCas9-VPR and MS2-MCP-p65-HSF1, or SpdCas9-TET1-CD and MS2-MCP
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Data_Sheet_2_CRISPR/Cas13d-Mediated Microbial RNA Knockdown.docx
RNA-guided and RNA-targeting type IV-D CRISPR/Cas systems (CRISPR/Cas13d) have recently been identified and employed for efficient and specific RNA knockdown in mammalian and plant cells. Cas13d posse
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File S2.zip
Annotated sequence files in .ape format (comparable with Genbank) of knock-ins generated by CRISPR/Cas9-mediated genome editing. Unmodified genomic sequence is also provided.
Figshare2023-03-14 更新20
Targeting double-strand break indel byproducts with secondary guide RNAs improves Cas9 HDR-mediated genome editing efficiencies
We report a general strategy (the double tap method) to improve HDR-mediated precision genome editing efficiencies that takes advantage of the reproducible nature of indel sequences.
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Table1_Efficient Genome Editing by a Miniature CRISPR-AsCas12f1 Nuclease in Bacillus anthracis.DOCX
A miniature CRISPR-Cas12f has been demonstrated to serve as an effective genome editing tool in gram negative bacteria as well as human cells. Here, we developed an alternative method to edit the geno
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