Study design of four-week repeated intramuscular dose toxicity study in Sprague-Dawley rats and intradermal irritation study in New Zealand white rabbits.
Standard safety assessment of U. dioica L. aqueous extract in BALB/c mice with two different injection routes, intramuscular (IM) and intralesional (IL).
The objective of a long-term carcinogenicity study is to observe test animals for a major portion of their life span for the development of neoplastic lesions during or after exposure to various doses
Organisation for Economic Co-operation and Development20
