Single or multiple-dose regimen of TIP in PVM infection did not have an effect on weight loss, clinical score and lung cellular response.

A: Change in body weight expressed as the percentage of the original weight of PVM-infected mice that received 80 µg of TIP in 60 µl saline (black bars) or saline (white bars) on day 5 after infection with PVM. B: Mean clinical score of PVM-infected mice that received 80 µg of TIP in 60 µl or saline on day 5 after infection with PVM, examined at daily intervals according to a standardized scoring system. C: Total polymorhonuclear neutrophils (PMN) measured in bronchoalveolar lavage fluid of PVM-infected mice that received 80 µg of TIP in 60 µl saline or saline on day 5 after infection with PVM. The graphs represent the mean of 4–6 mice at each time-point (± SEM). *p