Investigating the solution conformation and mechanism of action of antimicrob...

B2FIND2026-04-11 收录

抗菌药物研发

药物作用机制

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Bacterial resistance to antibiotic therapy is a major world health problem, which has been exacerbated by a decline in antimicrobial drug development and the emergence of...

Next Generation Sequencing Facilitates Quantitative Analysis of transcriptomes in Multiple Myeloma (MM) cell lines treated with DMSO and Indirubin-3’-monoxime (I3MO)

癌细胞转录组

药物作用机制

To determine what signaling pathways are affected by I3MO in MM cells, 5 MM cell lines including ANBL6, ANBL6 BR, ARP1, RPMI-8226, and U266, were cultured with DMSO or 5/10µM I3MO for 48 h. Total RNAs

NIAID Data Ecosystem60

Momordicine I Suppresses Glioma Growth by Promoting Apoptosis and Impairing Mitochondrial Oxidative Phosphorylation. Momordicine I Suppresses Glioma Growth by Promoting Apoptosis and Impairing Mitochondrial Oxidative Phosphorylation

神经胶质瘤治疗

药物作用机制

RNA microarray was performed from glioma cell LN229 and GBM8401 that were treated with Momordicine (10 microM) for 48hr in comparison to DMSO vehicle control Overall design: To study the growth inhibi

NIAID Data Ecosystem30

Tungstate has no effect on KCa3.1 (IK1) channel activity.

离子通道功能

药物作用机制

(A) Whole-cell recordings of KCa3.1 in murine 3T3 fibroblasts. KCa3.1 currents were pre-activated by infusion of 1 μM Ca2+ via the patch-pipette as previously described [38]. Pre-activated currents (c

Figshare2015-12-03 更新10

Inhibitory Effects of Vinpocetine on the Progression of Atherosclerosis Are Mediated by Akt/NF-κB Dependent Mechanisms in apoE -/- Mice

动脉粥样硬化治疗

药物作用机制

Background Recent studies have found additional roles for vinpocetine, a potent phosphodiesterase type I inhibitor, in anti-proliferation and anti-inflammation of vascular smooth muscle cells and canc

NIAID Data Ecosystem60

A Dual-Mechanism Luminescent Antibiotic for Bacterial Infection Identification and Eradication

抗菌药物研发

细菌感染成像诊断

Due to the rapid emergence of antibiotic-resistant bacteria, there is a growing need to discover antibacterial agents. Herein, we design and synthesize a compound of TPA2PyBu that kills both Gram-nega

NIAID Data Ecosystem20

Investigating the solution conformation and mechanism of action of antimicrob...

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