Human DHX9 in Complex with Compound 1 and ADP

Human DHX9 in Complex with Compound 1 and ADP Descriptor: 1-ethyl-N-[3-(methanesulfonamido)phenyl]-5-methyl-1H-pyrazole-3-carboxamide, ADENOSINE-5'-DIPHOSPHATE, ATP-dependent RNA helicase A, ... Authors: Lockbaum, G.J, Lee, Y.-T, Sickmier, E.A, Boriack-Sjodin, P.A, Grigoriu, S. Deposit date: 2024-12-10 Release date: 2025-05-07 Last modified: 2025-05-21 Method: X-RAY DIFFRACTION (3.26 Å) Cite: Discovery of ATX968: An Orally Available Allosteric Inhibitor of DHX9. J.Med.Chem., 68, 2025人源DHX9与化合物1及二磷酸腺苷（ADP）复合物的结构描述：1-乙基-N-[3-(甲磺酰胺基)苯基]-5-甲基-1H-吡唑-3-甲酰胺、腺苷-5'-二磷酸、ATP依赖RNA解旋酶A……作者：Lockbaum, G.J.、Lee, Y.-T.、Sickmier, E.A.、Boriack-Sjodin, P.A.、Grigoriu, S. 存档日期：2024-12-10 发布日期：2025-05-07 最后修改日期：2025-05-21 实验方法：X射线衍射（3.26 Å） 引用文献：《ATX968的发现：一种可口服的DHX9变构抑制剂》，载于《药物化学杂志（J.Med.Chem.）》，2025年，第68卷。