Transcriptional profiling of naïve and in vitro activated B cells from WT and DOT1L KO mice. Transcriptional profiling of naïve and in vitro activated B cells from WT and DOT1L KO mice

We studied the role of the histone methyltransferase DOT1L in B cell development and differentiation. Here we generated RNA-seq data naive B cells from (WT) MB1+/-;Dot1L+/+ and Dot1L KO (MB1+/-;Dot1Lfl/fl) mice. This data was to define tissue specific expression signatures and it was compared with H3K79me2 ChIP-seq data from the same subsets. Overall design: RNA-seq from MACS sorted CD19+ naïve and actiavted B cells WT and Dot1L KO mice