Highly Diastereo- and Enantioselective Tandem Reaction toward Functionalized Pyrrolidines with Multiple Stereocenters
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An efficient asymmetric tandem dual Michael reaction that constructs three contiguous stereocenters in acyclic open-chain systems with very high enantioselectivity and diastereoselectivity has been developed. This protocol provides a reliable and rapid approach for synthesis of chiral pyrrolidines with multiple stereocenters.
创建时间:
2011-10-21



