*In order to evaluate stability of the Cdc34UBC replicas, sample simulations using as starting structure the Cdc34 model which has been generated using as template Ube2g2 NMR structure have been exten
The nonmevalonate pathway is responsible for isoprenoid production in microbes, including H. pylori, M. tuberculosis and P. falciparum, but is nonexistent in humans, thus providing a desirable route f
AAA ATPases form a functionally diverse superfamily of proteins. Most members form homo-hexameric ring complexes, are catalytically active only in the fully assembled state, and show co-operativity am
