Endothelin pathways

Endothelin-1 is a bicyclic 21 amino acid peptide, produced primarily in the endothelium. It is a potent stimulus of long-lasting and persistent vasoconstriction. It also has a role as a stimulus of inflammation, oxidative stress and cellular proliferation.内皮素-1是一种由21个氨基酸组成的环状肽，主要在血管内皮细胞中产生。它是一种强烈的血管收缩刺激剂，能引发持久和持续的血管收缩反应。此外，内皮素-1在炎症、氧化应激和细胞增殖的刺激作用中也扮演着一定的角色。