MicroRNA Expression of Mouse Cochleae during Aging. Mus musculus

To identify which miRNAs are involved in the onset and progression of age-related hearing loss in the mammalian cochlea We used miRNA microarrays to screen miRNAs which exhibit the differential expression in the expressing levels during aging of the cochlea Overall design: The organ of Corti (OC), one of the major pathological sites of presbycusis in cochlea, was collected separately at 3 timepoints during the life span. Two strains were selected: C57BL/6J and CBA/J. The selected time points were: Postnatal 21 days (P21), 3 month (3m) and 9 month (9m) for C57 mice, and P21, 9m, 16m for CBA mice.