Rocaglates are a class of eukaryotic translation initiation inhibitors that are being explored as chemotherapeutic agents. They function by targeting eukaryotic initiation factor (eIF) 4A, an RNA heli

NIAID Data Ecosystem30

IKAROS and MENIN are Functionally Cooperative Therapeutic Targets in Acute Myeloid Leukemia [RNA-seq]

急性髓系白血病

RNA-seq转录组学

Using RNA-seq we examined the transcriptional changes following IKAROS degradation, MENIN-inhibition or the drug combination in the MOLM13 and MV4;11 human MLL-fusion acute myeloid leukemia cell lines

NIAID Data Ecosystem20

CBX4 role in U2OS/MTX300

肉瘤转移机制

RNA-seq转录组学

In our study, we found that CBX4 was critical to osteosarcoma metastasis.CBX4, also known as polycomb 2 (Pc2), belongs to the CBX protein family, including CBX2, 4, 6, 7, and 8, which has been shown t

NIAID Data Ecosystem30

NFs RNA-Seq Transcriptome or Gene expression

神经纤维瘤基因表达

RNA-seq转录组学

Total RNA from NF cells treated with or without P4 for 96h was extracted according to the manufacturer's protocol. RNA was subjected to RNA-Seq analysis.

NIAID Data Ecosystem20

RNA-seq of different gene expression in liver cancer

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