Resistance to small molecule drugs often emerges in cancer cells, viruses, and bacteria as a result of the evolutionary pressure exerted by the therapy. Protein mutations that directly impair drug bin
While significant progress has been made in developing approaches to study amyloid self-assembly leading to homomeric fibril formation by identical proteins, our understanding of heteromeric cross-int
aValues represent an average of three separate experiments. Drug binding was measured by tryptophan fluorescence for Et, MG and R6G and by isothermal titration calorimetry for Dq.
