Accumulating evidence demonstrates that CD8 T cells contribute to protection from severe DENV disease and vaccine efficacy. Nevertheless, the molecular programs associated with DENV-specific CD8 T cel
A heterozygous IRF4 missense variant located within the interferon activation domain of the encoded IRF4 protein (mutIAD) was identified in three patients from a multigenerational family suffering fro
Langerhans cells and macrophages were isolated from adult skin that was collagenase digeseted overnight by FACS. Adult spleen was collagenase digested for 1hr and the pDCs were isolated by FACS. Gene
Langerhans cells (LC) coordinate immune homeostasis at the human epidermis, proficent in initiating immunogenic and tolerogenic immune responses. To investigate the transcriptomic mediators of human L
