Aberrant telomerase reverse transcriptase (TERT) expression is crucial for tumour survival and cancer cells escaping apoptosis. Multiple TERT-locus variants at 5p15 have been discovered in association
To date there are very few tools to reverse the induced dedifferentiation program in CRPC and to improve the response to the androgen deprivation therapy. Here we report that MAT2A is an important onc
A specialized ChIP protocol to facilitate the investigation of protein-DNA interactions in E. diaphana gene regulation is presented. The cross-linkingand chromatin extraction steps were optimized for
Epigenetic silencing mediated by CpG methylation is a common feature of many cancers. Characterizing aberrant DNA methylation changes associated with tumor progression may identify potential prognosti
