Discovery of novel microRNAs in rat kidney using microarray analyses

MicroRNAs are small non-coding RNAs that regulate a variety of biological processes. In the last version of the miRBase database (Release 17), 720 mouse microRNAs are accompanied by only 408 rat microRNAs. Given the importance of rat as a model organism, we used next generation sequencing and microarray technologies to discover novel microRNAs in rat kidneys.微小RNA（microRNAs）是一类调控多种生物学过程的小型非编码RNA。在miRBase数据库第17版（Release 17）中，共收录720种小鼠微小RNA，而大鼠微小RNA仅为408种。鉴于大鼠作为模式生物的重要性，本研究采用下一代测序技术与基因芯片技术，在大鼠肾脏组织中发掘新型微小RNA。