蛋白质翻译后修饰数据库

SysPTM提供了一个系统并复杂的蛋白质组翻译后修饰研究平台，不仅配备可手动策划并修改多类型数据的知识库，还拥有4个已发展完善并深入的数据挖掘工具。目前，SysPTM包含经实验确认的53235个蛋白质上的471109修饰位点的详细数据，覆盖50多个修饰类型。数据来源于公共资源，包括5个数据库、4个网络服务器和三百多名同行评议的质谱分析的论文。蛋白质注释包括包含蛋白质家族数据库域，KEGG途径，GO功能分类和直接同源组，都集成到数据库中。五个在线工具已经开发和整合，包括：PTMBlast、PTMPathway、PTMPhylog、PTMCluster和PTMGO。在SysPTM，单一类型和多类型的修饰信息可以在一个完整的生物背景中进行系统地研究。SysPTM 为未来翻译后修饰研究做出了重要的贡献。SysPTM is a systematic and sophisticated platform for proteomic post-translational modification (PTM) research. It is equipped with a manually curated knowledge base that supports both curation and editing of multi-type data, and also incorporates four well-developed and in-depth data mining tools. Currently, SysPTM contains detailed data for 471,109 modification sites on 53,235 experimentally confirmed proteins, covering more than 50 modification types. All data are sourced from public resources, including 5 databases, 4 web servers, and over 300 peer-reviewed mass spectrometry papers. Protein annotations including protein family domains, KEGG pathways, GO functional classifications, and orthologous groups are all integrated into the database. Five online tools have been developed and integrated, including PTMBlast, PTMPathway, PTMPhylog, PTMCluster, and PTMGO. In SysPTM, both single-type and multi-type modification information can be systematically studied within a comprehensive biological context. SysPTM has made significant contributions to future post-translational modification research.

搜集汇总

背景与挑战

背景概述

蛋白质翻译后修饰数据库（SysPTM）是一个综合性的蛋白质组学研究平台，提供经实验验证的超过47万个修饰位点数据，涵盖50多种修饰类型，并整合了多个数据挖掘工具和生物信息注释。该数据库由公共资源构建，支持系统研究单一和多类型修饰，归属于国家人口健康科学数据中心，可通过线上方式完全共享访问。