Additional file 5 of SRSF3 and SRSF7 modulate 3′UTR length through suppression or activation of proximal polyadenylation sites and regulation of CFIm levels
We adapted tag-based methods in conjunction with SOLiD and Illumina deep sequencing platforms to determine the precise 5â and 3â ends of VACV early mRNAs and map the transcription start sites (TSS
The main goal of this proposal is to build a comprehensive understanding of a new layer of eukaryotic 3’-end precursor-mRNA processing, with focus on the Cleavage Stimulation Factor (CStF) complex. Th
In frontotemporal dementia and amyotrophic lateral sclerosis, the RNA-binding protein TDP-43 is depleted from the nucleus. TDP-43 loss leads to cryptic exon inclusion but a role in other RNA processin
The post-transcriptional fate of messenger RNAs (mRNAs) is largely dictated by their 3' untranslated regions (3'UTRs), which are defined by cleavage and polyadenylation (CPA) of pre-mRNAs. We used pol
The yeast mRNA export adaptor Yra1 binds the Pcf11 subunit of cleavage-polyadenylation factor CF1A linking export to 3'-end formation. We found a surprising consequence of this interaction is that Yra
