Machine Learning Ensemble Directed Engineering of Genetically Encoded Fluorescent Calcium Indicators.
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This upload contains all data collected and presented in (https://doi.org/10.1101/2023.04.13.536801). The files are zipped files associated with main figures, supplemental figures, and supplementary tables. We have additionally attached a .zip file that includes the Chen<sup>1</sup> and Dana<sup>2</sup> datasets used to run our model, as well as an amino acid property matrix derived from AAINDEX<sup>3</sup>. <br> Dataset Refs: 1. Chen, T.-W. <em>et al.</em> Ultrasensitive fluorescent proteins for imaging neuronal activity. <em>Nature</em> <strong>499</strong>, 295–300 (2013). 2. Dana, H. <em>et al.</em> High-performance calcium sensors for imaging activity in neuronal populations and microcompartments. <em>Nat. Methods</em> <strong>16</strong>, 649–657 (2019). 3. AAindex. (https://www.genome.jp/aaindex/)
