Functional genomics in perinatal asphyxia and fetal asphyctic preconditioning in the brain

Fetal asphyctic (FA) preconditioning is effective in attenuating brain damage incurred by a subsequent perinatal asphyctic insult. Unraveling mechanisms of this endogenous neuroprotection, activated by FA preconditioning, is an important step towards new clinical strategies for asphyctic neonates. Genomic reprogramming is thought to be, at least in part, responsible for the protective effect of preconditioning. Therefore, we investigated whole genome differential expression in the preconditioned rat brain.胎儿窒息（Fetal asphyctic, FA）预处理可有效减轻后续围产期窒息损伤所致的脑损伤。阐明该经FA预处理激活的内源性神经保护机制，是研发针对窒息新生儿的新型临床策略的重要环节。现有研究认为，基因组重编程至少部分介导了预处理的保护效应。因此，本研究对经预处理的大鼠脑组织开展了全基因组差异表达分析。